ࡱ> { I4bjbjBrBr Dj  u+ ,,,8dll,ZR<:v4} D!eZgZgZgZgZgZgZ$8]_Z$$$ZZ8'8'8'$eZ8'$eZ8'8'qUlqYp*$V*QZZ0ZWj`J%`TqY`qYe">",8'"$"#e"e"e"ZZ&Xe"e"e"Z$$$$`e"e"e"e"e"e"e"e"e" :  Insert Title of Protocol The title should be descriptive and concise. It provides the first impression and a lasting reminder of the content and design of the study. When applying for funding, the choice of words in the title is particularly important because it influences the decision on which study section (or review group) will receive the protocol. Example title: A Comparison of Open, Hand-assisted and Laparoscopic Bowel Resection with Regards to the Incidence of Small Bowel Obstruction and Ventral Hernia Authors:Insert the Full Name of Each Investigator and Degree(s)Program:Insert the Name of Program the Author(s) Represent; use footnotes to link authors with programsInstitutions:Insert the Name of Institution the Author(s) Represent; use footnotes to link authors with institutionsCorresponding Author:Insert the Full Name of Investigator and Degree(s) Insert Department Name Insert Address Insert Phone; Insert Fax Insert Email  Protocol/version #: Current Version Date:Previous IRB Approved Version Dates: CONFIDENTIAL This document is confidential and the property of individual. No part of it may be transmitted, reproduced, published, or used by other persons without prior written authorization from the author. List of Abbreviations (e.g.) ICH International Conference on Harmonisation CRF Case Report Form GCP Good Clinical Practice HREB Health Research Ethics Board Table of Contents (***Notice*** Table of Contents will update automatically)  TOC \o "1-3" 1 Introduction/Significance 3 2 Study Objectives 3 3 Patients and methods 3 3.1 Study Design 3 3.1.1 General Design 3 3.1.2 Primary Outcome Variable 3 3.1.3 Secondary Outcome Variables 3 3.2 Subject Selection and Withdrawal  PAGEREF _Toc176059675 \h 6 3.2.1 Inclusion Criteria  PAGEREF _Toc176059676 \h 6 3.2.2 Exclusion Criteria 4 3.3 Study Procedures 4 3.4 Statistical Plan 4 3.4.1 Sample Size Determination 4 3.4.2 Statistical Methods 4 4 Data Handling and Record Keeping 4 4.1 Confidentiality 4 4.2 Records Retention 5 4.3 Regulatory Binder 5 5 Auditing and Inspecting 5 6 BUDGET 5 7 Publication Plan 6 8 references 6 9 Attachments 6  Introduction/Significance The introduction should open with remarks that state this document is a clinical research protocol and the described study will be conducted in compliance with the protocol, Good Clinical Practices standards and associated Federal regulations (i.e Health Canada), and all applicable institutional research requirements. The remaining paragraphs in this section should contain a background discussion of studies relevant to the research question(s). References should be cited throughout. The cited literature will be included in the Reference section. Study Objectives Describe the specific aims for the study. This should include both primary and any secondary objectives, as illustrated: Primary Objective To assess the efficacy of XXXX on decreasing infarct size as measured by Sestamibi scanning. Secondary Objective To assess the safety and tolerability of two doses of XXXX in subjects with acute myocardial infarction. Patients and Methods Study Design General Design Describe the study design of the study (e.g. case series, case-control, retrospective cohort, nested case-control) The two most commonly used designs for observational studies are (A) case-control studies (including nested case-control studies) and (B) cohort studies. In the former, the study groups are chosen on the basis of their disease or outcome of interest. In a cohort study the comparison groups are identified according to an exposure of interest. A description of the design should be given, along with details of any matching and blinding used. Cross-sectional studies are also discussed in (C). Case-control studies Definition of study groups: Describe an objective definition for the disease or outcome of interest and use this to define the cases. Describe the appropriate control group for the particular group of cases. In general the controls should be sources from a similar population as the cases, the only difference being that they do not have the outcome of interest. Matching (if relevant): Describe the matching factor(s) and how the matching will be done. The main purpose of matching is to control for confounding. By matching on age, for example, we are attempting to ensure the cases and controls have the same (or similar) age distribution. Blinding and avoiding bias: List the measurements that are to be blinded and how this will be done. Blinding is a technique used to minimize bias. In observational studies, the minimization of ascertainment bias can be helped by blinding (e.g. If subjects in a case control study are to be interviewed to assess exposure status, then the interviewer should, if possible, be blind to the outcome of the subjects) Methods used to minimize other types of bias should be described (e.g. using multiple sources of information can help minimize verification bias). (B) Cohort Studies Definition of study groups: The exposure of interest should be clearly described and used to define the exposed group. Groups like doctors, civil servants, surgery patients are often chosen as the source of the groups because they are easy to define or monitor. In these situations an internal comparison group without the exposure of interest would be used (e.g. doctors who smoke and doctors who do not smoke). Sometimes groups with special exposures are chosen (e.g. brewery workers, workers in nuclear power stations) and in these cases an external comparison group would need to be found. Blinding and avoiding bias: List the measurements that are to be blinded and how this will be done. Blinding is a technique used to minimize bias (e.g. in a prospective cohort study where subjects are being followed up in the future, the researcher who assess any outcome measures should, if possible, be blinded to exposure status). (C) Cross-sectional studies: In cross-sectional studies the exposure status and disease status are assessed at a single point in time (e.g. a sample survey; 2001 census). It is therefore not possible to establish whether the exposure preceded or resulted from the disease. However, data from these studies are useful in providing information about the health status and needs of a population. They are sometimes called prevalence studies. Selecting the study groups has the same problems/ features as with cohort studies. Response rates are also often a problem and the strategy used to recruit a representative sample and for maximizing the response rate should be given. (D) Other types of studies Other types of observational studies may involve only one group of subjects. For example, in a method comparison study, measurements will be taken on a group of subjects using two (or more) methods. The guidelines set out in this document still apply, the main difference being that a second group of subjects is not used. Primary Outcome Variable Describe the primary outcome variable to be analyzed in the study (e.g. could be length of stay or mortality, depending upon the primary objective of the study). Secondary Outcome Variables Describe any secondary outcome variables to be analyzed in the study. Subject Selection and Withdrawal Inclusion Criteria Create a list of criteria subjects must meet to be eligible for study inclusion (e.g. age, gender, target disease, concomitant disease if required, etc.). Exclusion Criteria Create a list of criteria that would exclude a subject from the study. Study Procedures In this section, describe what data will be accessed, and how they will be obtained. All variables to be extracted must be identified. The variables should all be listed on your data sheet. The time period for the charts to be reviewed, as well as the institutions from which the records will be acquired, should also be listed in this section. Statistical Plan Sample Size Determination Describe how the sample size was determined for this study. The sample size should be based upon the primary outcome variable. If the authors have determined that a sample size estimation was not necessary, please provide the rationale. Statistical Methods Describe how the data will be summarized (i.e. mean + SD, medians and ranges, percentages with 95% confidence intervals, etc). Identify the statistical test for the analysis of the primary outcome variable. Define the tests for the analysis of the secondary outcome variables. Set the level of significance, i.e. significance will be assessed at p < 0.05. If no statistical tests are planned, denote that only summary statistics will be used. Data Handling and Record Keeping Data to be collected: If using an established database permission to use the data must be sought and a detailed description of how (and by whom) the data will be collected for the study should be given. Also, an example of the data extraction form used to obtain the data for your study should be included. Provide a detailed list of all data (outcome variables, explanatory variables, potential confounding variables etc) to be collected, with each description including: source of the data (e.g. patient questionnaires, patient notes, electronic data, procedure) time point for collection (baseline, during treatment, at follow up point) who will collect the data why the data is being collected (e.g. baseline comparison data, primary outcome, important prognostic / explanatory /confounding variable) whether the data is from a standardized tool (e.g. McGill pain score) involves a procedure (in which case full details should be supplied). If a non-standard tool is to be used, detail on reliability and validity should be given. what form the data will take (e.g. binary, continuous (numeric), time to event) Describe methods used to maximize completeness of data (e.g. telephoning patients who have not returned postal questionnaires) Include data collection forms and questionnaires as appendices Confidentiality Describe how confidentiality of records will be maintained. Records Retention For retrospective studies, summarize the record retention plan applicable to the study. Regulatory Binder The investigators are required to maintain a regulatory binder containing all information pertinent to the study; a statement to this effect should be included. Study Auditing and Inspecting Describe the plan for auditing and inspection, if applicable. Budget This section should provide a brief summary of the expenses estimated for the study, as well as the projected funding source. Publication Plan References This is the literature cited section for any information referenced in the protocol. It should be organized as found in a medical journal such as JAMA or the NEJM. 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